African health sciences
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African health sciences · Mar 2023
Clinical TrialComparative cardiac effects of antimalarial drug halofantrine with or without concomitant administration of kolanut or fluconazole in healthy volunteers.
There is rekindled interest in the cardiotoxicity of antimalarial medicines. Halofantrine is associated with QT interval prolongation. Fluconazole and kolanut alter the pharmacokinetics of halofantrine. ⋯ Concomitant intake of kolanut with halofantrine was significantly decrease cardiac effect of halofantrine.
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African health sciences · Mar 2023
Assessment of knowledge and socioeconomic status of caregivers of children with malnutrition at a district hospital in Ghana.
Malnutrition is a significant public health problem and is a major cause of morbidity and mortality in children. ⋯ Lower level of caregivers' education and large family size were risk factors for developing malnutrition among children.
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African health sciences · Mar 2023
Neonatal pain perception, management and review of practises among medical workers in Nigeria newborn units.
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The perception of pain is variable and knowledge may not match practise. ⋯ Perception of pain was high but did not match knowledge and practice of NPM. Formal education on NPM was lacking in the training of HCW.
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African health sciences · Mar 2023
The integrity of psychophysical visual function in non-immunocompromised PLHIV (NIPLHIV) without retinitis on antiretroviral therapy (ART).
The present study investigated the integrity of contrast sensitivity (CS), colour vision, and pattern evoked vision potentials (VEP) in non-immunocompromised people living with HIV (NIPLHIV) without retinitis. ⋯ Contrast sensitivity function, colour vision, and VEP were uncompromised in NIPLHIV. Associations between CD4 counts with F100 total error scores and P100 latency may aid in the surveillance of vision of NIPLHIV.
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African health sciences · Mar 2023
Meta AnalysisPrevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis.
Depression is one of the most common mental health problems comorbid with tuberculosis. However, a consolidated picture of the prevalence of depression among tuberculosis patients in East Africa remains unknown. This systematic review and meta-analysis provide new understandings by systematically examining evidence concerning the prevalence of depression among tuberculosis patients in East Africa. ⋯ A total of 409 studies were accessed. However, only 29 qualified for a full-text review, and 9 studies with a population of 2838 were included in the qualitative description and quantitative analysis. The pooled prevalence estimate of depression amongst tuberculosis patients was 43.03 % (34.93, 51.13). The highest prevalence was observed in Kenya, with 45.71% (29.26, 62.16); a similar rate was observed in Ethiopia, with 45.11 % (34.60, 55.62). Subgroup analysis based on screening tool was used: 45.71% with BDI and 41.53% with PHQ.