African health sciences
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African health sciences · Mar 2021
Meta AnalysisUric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials.
This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity. ⋯ Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-β and serum lipids.
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African health sciences · Mar 2021
Meta AnalysisIndian scenario of IgA nephropathy: a systematic review and meta-analysis.
IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of IgAN and its clinical features in different studies from India. ⋯ The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic hematuria were common clinical features.
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African health sciences · Mar 2021
The impact of selenium administration on severe sepsis or septic shock: a meta-analysis of randomized controlled trials.
The efficacy of selenium administration to treat severe sepsis or septic shock remains controversial. We conduct a systematic review and meta-analysis to explore the impact of selenium administration on severe sepsis or septic shock. ⋯ Selenium administration results in notable decrease in all-cause mortality and length of hospital stay, but shows no substantial influence on the 28-day mortality, length of ICU stay, duration of vasopressor therapy, the incidence of acute renal failure, adverse events, and serious adverse events for septic patients.
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African health sciences · Mar 2021
Multicenter StudyCharacteristics and outcomes of patients with multiple myeloma at the Uganda Cancer Institute.
Data on multiple myeloma (MM) in sub-Sahara Africa is scarce. In Uganda, there is a progressively increasing incidence of MM over the years. ⋯ Most patients with multiple myeloma at the UCI were diagnosed at a relatively young age, presented with late stage disease and bone pain, and had a shorter survival time. Factors associated with worse survival were Durie-Salmon stage III and LDH >225 U/L.