African health sciences
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African health sciences · Dec 2022
Meta AnalysisA meta-analysis and experimental data for multidrug resistance genes in breast cancer.
Increasing trend of breast cancer incidence worldwide is a known fact. This curable disease may become fatal if drug resistance is developed leading to metastatic cancerous tissue. ⋯ These findings suggest that these genes are associated with breast cancer.
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African health sciences · Sep 2022
Meta AnalysisEmpagliflozin for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials.
The efficacy of empagliflozin for non-alcoholic fatty liver disease remains controversial. This meta-analysis aims to explore the influence of empagliflozin versus placebo on the treatment of non-alcoholic fatty liver disease and we have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through July 2021 for related randomized controlled trials (RCTs). ⋯ Compared with control group for non-alcoholic fatty liver disease, empagliflozin treatment has no improvement in controlled attenuation parameter (CAP) score, hepatic steatosis and liver stiffness measurement (LSM) score, alanine aminotransferase (ALT), aspartate-aminotransferase (AST), low density lipoprotein (LDL) or triglyceride (TG). These indicate that empagliflozin treatment may be not effective for non-alcoholic fatty liver disease.
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African health sciences · Sep 2022
Meta AnalysisThe effect of liraglutide on renal function in type 2 diabetes: a meta-analysis of randomized controlled studies.
The efficacy of liraglutide on renal function in type 2 diabetes remains controversial. We conduct a systematic review and meta-analysis to explore the influence of liraglutide versus placebo on renal function in type 2 diabetes. ⋯ Liraglutide treatment may provide some benefits for protecting renal function in type 2 diabetes.
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African health sciences · Sep 2022
Meta AnalysisAssociation between physical exercise and all-cause and CVD mortality in patients with diabetes: an updated systematic review and meta-analysis.
Physical activity is recommended in guidelines for treatment for diabetes, but the association between physical activity and mortality among diabetic patients has not been extensively studied. ⋯ Physical activity reduced the risk of total and CVD mortality among patients with diabetes, in particular in diabetic patients with old age (> 60 years), obesity and shorter duration of diabetes.
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African health sciences · Sep 2022
Meta AnalysisAssociation of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.
The relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy. ⋯ Our findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.