African health sciences
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African health sciences · Mar 2023
Association of pro-fibrinolytic receptor AnnexinA2 with tissue plasminogen activator/Inhibitor-1 in pre-eclampsia.
The clinical manifestations of pre-eclampsia are related to placental anti-angiogenic factor alteration. These variations are mainly due to the alteration of plasminolytic components. The study aims to compare the expression of plasminolytic components in the placenta of women with and without pre-eclampsia. ⋯ Decreased AnxA2 with increased expression of PAI-1 and tPA may be responsible for the altered fibrinolytic activity and play a significant role in pre-eclampsia pathogenesis.
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African health sciences · Mar 2023
Meta AnalysisGinger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials.
The efficacy of ginger supplementation remains controversial for non-alcoholic fatty liver disease. We conduct this meta-analysis to explore the influence of ginger supplementation versus placebo on the treatment of non-alcoholic fatty liver disease. ⋯ Ginger supplementation benefits to treat non-alcoholic fatty liver disease.
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African health sciences · Mar 2023
Meta AnalysisPrevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis.
Depression is one of the most common mental health problems comorbid with tuberculosis. However, a consolidated picture of the prevalence of depression among tuberculosis patients in East Africa remains unknown. This systematic review and meta-analysis provide new understandings by systematically examining evidence concerning the prevalence of depression among tuberculosis patients in East Africa. ⋯ A total of 409 studies were accessed. However, only 29 qualified for a full-text review, and 9 studies with a population of 2838 were included in the qualitative description and quantitative analysis. The pooled prevalence estimate of depression amongst tuberculosis patients was 43.03 % (34.93, 51.13). The highest prevalence was observed in Kenya, with 45.71% (29.26, 62.16); a similar rate was observed in Ethiopia, with 45.11 % (34.60, 55.62). Subgroup analysis based on screening tool was used: 45.71% with BDI and 41.53% with PHQ.
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African health sciences · Mar 2023
Meta AnalysisVitamin D deficiency in rheumatoid arthritis patients of India - a single-arm meta-analysis.
Vitamin D deficiency is commonly seen in patients with rheumatoid arthritis (RA). ⋯ The results demonstrate significant low levels of serum vitamin D levels in patients with RA and established a negative correlation of Vitamin D with RA disease activity. The current evidence suggests a rationale for Vitamin D supplementation in the management of RA.
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African health sciences · Mar 2023
ReviewStaging of COVID-19 disease; using selected laboratory profiles for prediction, prevention and management of severe SARS-CoV-2 infection in Africa-review.
There are many uncertainties on the future management of the coronavirus disease 19 (COVID-19) in Africa. By July 2021, Africa had lagged behind the rest of the world in Covid-19 vaccines uptake, accounting for just 1.6% of doses administered globally. During that time COVID 19 was causing an average death rate of 2.6% in Africa, surpassing the then global average of 2.2%. ⋯ For each of the studies, we extracted data on pathophysiology, selected clinical chemistry and immunological tests, clinical staging and treatment. Our review reports a gross unmet need for vaccination, inadequate laboratory capacity for immunological tests and the assessment of individual immune status, clinical staging and prediction of disease severity. We recommend selected laboratory tools in the assessment of individual immune status, prediction of disease severity and determination of the exact timing for suitable therapy, especially in individuals with co-morbidities.