Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Aug 2016
Factor VIII chromogenic assays can be used for potency labeling and postadministration monitoring of N8-GP.
Essentials Chromogenic assays may be less variable than one-stage clot assays for measuring modified factor VIII. Chromogenic assays were evaluated for N8-GP potency labeling and postadministration monitoring. There was no significant difference between chromogenic assay kits for measuring N8-GP potency. Postadministration monitoring of N8-GP was comparable to turoctocog alfa for all kits tested. ⋯ C for N8-GP potency and showed comparable results for N8-GP and turoctocog alfa in simulated postadministration samples.