Chinese medical journal
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Chinese medical journal · Dec 2022
Randomized Controlled Trial Multicenter StudyEffect and safety of anaprazole in the treatment of duodenal ulcers: a randomized, rabeprazole-controlled, phase III non-inferiority study.
The pharmacokinetic and clinical behaviors of many proton pump inhibitors (PPIs) in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms. This non-inferiority study evaluated the efficacy and safety of the novel PPI anaprazole compared with rabeprazole. We also explored the influence of Helicobacter pylori ( H. pylori ) infection status and CYP2C19 polymorphism on anaprazole. ⋯ ClinicalTrials.gov, NCT04215653.
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Chinese medical journal · Dec 2022
Randomized Controlled TrialAdjunctive sepsis therapy with aminophylline (STAP): a randomized controlled trial.
Sepsis is a serious disease caused by infection. Aminophylline has anti-asthma and anti-inflammatory effects. We aimed to explore the safety and effect of aminophylline in sepsis. ⋯ Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.