Chinese medical journal
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Chinese medical journal · Jun 2024
Prognosis and outcome of intrauterine treatment of fetuses with critical congenital heart disease.
Intrauterine valvuloplasty is an innovative therapy, which promotes ventricular growth and function in some congenital heart diseases (CHDs). The technique remains challenging and can only be performed in a few centers. This study aimed to assess the feasibility and mid-term outcomes of fetal cardiac intervention (FCI) in fetuses with critical CHD in an experienced tertiary center. ⋯ Intrauterine FCI could be performed safely with good prognosis in critical CHD.
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Chinese medical journal · Jun 2024
Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model.
Homoharringtonine (HHT) is an effective anti-inflammatory, anti-viral, and anti-tumor protein synthesis inhibitor that has been applied clinically. Here, we explored the therapeutic effects of HHT in a mouse heart transplant model. ⋯ HHT promotes Treg cell differentiation and enhances Treg suppressive function by attenuating the TCR signaling pathway and upregulating the expression of Treg signature genes and IL-10 levels, thereby promoting mouse heart allograft acceptance. These findings may have therapeutic implications for organ transplant recipients, particularly those with viral infections and malignancies, which require a more suitable anti-rejection medication.