Pediatric blood & cancer
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Pediatric blood & cancer · Mar 2020
Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA-DPB1 typing.
New strategies to optimize donor selection for hematopoietic stem cell transplantation (HSCT) have mainly been evaluated in adults, but the disease spectrum requiring HSCT differs significantly in children and has consequences for the risk of complications, such as graft-versus-host disease (GvHD). ⋯ Implementing PIRCHE typing in the donor selection process for HSCT in children could particularly benefit children with nonmalignant diseases and support further validation of PIRCHE-based donor selection in a larger number of children treated at different sites.