Pediatric blood & cancer
-
Pediatric blood & cancer · Apr 2020
Multicenter StudyProtein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study.
There are no tests to identify critically ill children at high risk of deep venous thrombosis (DVT). In this exploratory study, we aimed to identify proteins that are associated with incident DVT in critically ill adolescents. ⋯ We identified candidate protein biomarkers for incident DVT. We plan to validate our findings in adequately powered studies.
-
Pediatric blood & cancer · Apr 2020
Vitamin D status in children with leukemia, its predictors, and association with outcome.
Children and adolescents with leukemia are potentially at high risk of vitamin D inadequacy, which may have clinical relevance for skeletal morbidity, infections, and cancer outcome. This study aimed to evaluate vitamin D status at the time of diagnosis to investigate its predictors and association with overall survival in children with leukemia. ⋯ It remains unclear whether vitamin D supplementation in pediatric leukemia patients will improve outcome.
-
Pediatric blood & cancer · Mar 2020
Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA-DPB1 typing.
New strategies to optimize donor selection for hematopoietic stem cell transplantation (HSCT) have mainly been evaluated in adults, but the disease spectrum requiring HSCT differs significantly in children and has consequences for the risk of complications, such as graft-versus-host disease (GvHD). ⋯ Implementing PIRCHE typing in the donor selection process for HSCT in children could particularly benefit children with nonmalignant diseases and support further validation of PIRCHE-based donor selection in a larger number of children treated at different sites.
-
Pediatric blood & cancer · Feb 2020
Helping parents prepare for their child's end of life: A retrospective survey of cancer-bereaved parents.
Most parents vividly recall the weeks, days, and moments preceding their child's death for years to come. Dissatisfaction with communication about their child's condition and lack of guidance can contribute to stress prior to a child's death. Based on findings from a study assessing the degree of preparation bereaved parents received and our collective clinical experience, the authors provide suggestions on end-of-life communication and guidance for parents. ⋯ Through quantitative and open-ended responses, this study identified specific medical and emotional issues about which parents wanted greater preparation. Future research to evaluate guidance strategies to reduce parental suffering prior to the child's death is needed.