Pharmacology
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Sennosides and related compounds are presumed to be severe cell poisons after prolonged ingestion. Some histological and ultrastructural studies in animals and man with such laxative misuse have revealed myenteric plexus and colonic epithelium injuries; but others have failed to point out identical data. ⋯ Electron microscopic observations showed nervous myenteric plexus abnormalities only in 1,8-dihydroxyanthraquinone-treated animals. These results suggest that sennosides have a good intestinal mucosa tolerance as opposed to aglycosidic-related compounds.
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Laxatives are classified according to their actions on the gut, and the special role and use of senna in the treatment of constipation are discussed. Standardised senna is the most physiological of all the non-fibre laxatives and is safe when used in appropriate dosage avoiding loose stools. Additional advice on bulk supplement should be given.