Cardiovascular revascularization medicine : including molecular interventions
-
Cardiovasc Revasc Med · Mar 2019
Meta AnalysisUpdated meta-analysis of closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
Among patients with cryptogenic stroke, PFO closure has remained controversial. We hypothesized that with the cumulative number of subjects in randomized controlled trials (RCTs), there is now sufficient power to ascertain whether PFO closure in patients with cryptogenic stroke improves the risk of stroke. ⋯ This meta-analysis of 6 RCTs demonstrated benefits of PFO closure for secondary prevention of stroke among patients with cryptogenic stroke and small increase in risk of new onset atrial fibrillation.