Ortopedia, traumatologia, rehabilitacja
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Ortop Traumatol Rehabil · May 2015
Comparative StudyEffect of Single Preoperative Dose of Tranexamic Acid on Blood Loss and Transfusion in Hip Arthroplasty.
The aim of the study was to assess the effect of a single intravenous dose of tranexamic acid administered before surgery in patients undergoing total cementless hip arthroplasty on: intra-, post-, and perioperative blood lost, the number of patients requiring transfusion, the incidence of thromboembolic complications Material and methods. The study enrolled 124 patients, who were randomly divided into two groups. The experimental group (61 patients) received an intravenous dose of 15 mg/kg of tranexamic acid 20 minutes before the skin incision, while the control group (63 patients) did not receive this drug. We analysed intraoperative blood loss (volume of blood in the aspirator), postoperative blood loss (volume of blood drained), total perioperative blood loss, and the number of patients requiring transfusion as well as the number of thromboembolic complications in both groups. ⋯ 1. The administration of 15 mg/kg of tranexamic acid 20 minutes before surgery decreases the need for postoperative transfusion of allogeneic blood due to a significant reduction in intra-, post-, and perioperative blood loss. 2. Seeing that this method does not increase the number of thromboembolic complications and is simple and inexpensive, it should be considered worthy of recommendation in total cementless hip arthroplasty.