International journal of obesity : journal of the International Association for the Study of Obesity
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Observational Study
Are adipokines the missing link between obesity, immune response, and outcomes in severe COVID-19?
Obesity is commonly reported in COVID-19 patients and is associated with poorer outcomes. It is suggested that leptin could be the missing link between obesity and severe COVID-19. Our study aimed to unravel the link between adipokines, COVID-19 status, immune response, and outcomes in severe pneumonia. ⋯ ClinicalTrials.gov: NCT03505281.
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Patients with obesity are at increased risk of severe COVID-19, requiring mechanical ventilation due to acute respiratory failure. However, conflicting data are obtained for intensive care unit (ICU) mortality. ⋯ COVID-19 patients admitted to the ICU with moderate obesity had a lower risk of death than the other patients, suggesting a possible obesity paradox.