Journal of diabetes
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Journal of diabetes · Mar 2013
Dietary supplementation with Ipomoea aquatica (whole leaf powder) attenuates maternal and fetal oxidative stress in streptozotocin-diabetic rats.
The rate of congenital anomalies, as well as morbidity and mortality of both the mother and fetus, is increased in diabetic pregnancy. Oxidative stress (OS) has been implicated in these effects because of the beneficial effects of several antioxidants in diabetic embryopathy. In the present study, we assessed attenuation of maternal and fetal OS and diabetic embryopathy by Ipomoea aquatica Forsk. (Convolvulaceae). ⋯ The data suggest that IA supplementation during pregnancy provides considerable protection against diabetes-induced OS in the mother and fetus. Thus, I. aquatica may be an effective therapeutic supplement.
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Journal of diabetes · Mar 2013
Randomized Controlled TrialEfficacy and safety of sitagliptin added to ongoing metformin and rosiglitazone combination therapy in a randomized placebo-controlled 54-week trial in patients with type 2 diabetes.
New therapeutic approaches are needed to improve glycemic control in patients with type 2 diabetes (T2D), a progressive disorder that often requires combination therapy. The present study assessed the efficacy and safety of sitagliptin as add-on therapy to metformin and rosiglitazone in patients with T2D. ⋯ In patients with T2D, the addition of sitagliptin for 54 weeks to ongoing therapy with metformin and rosiglitazone improved glycemic control and was generally well tolerated compared with placebo.