Therapeutic delivery
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Therapeutic delivery · Nov 2012
Highly loaded nanoparticulate formulation of progesterone for emergency traumatic brain injury treatment.
Progesterone (PG), a promising therapeutic for treating traumatic brain injury, has been difficult to formulate into a high-dose/low-volume form for emergency intravenous administration due to its hydrophobicity and crystallinity. ⋯ This formulation can allow for administration of therapeutically viable concentrations of PG, which has been impossible with all previously reported nanoparticulate formulations because of low drug loadings and concentrations.