Chest
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Randomized Controlled Trial
Deterioration of Nighttime Respiratory Mechanics in Chronic Obstructive Pulmonary Disease: Impact of Bronchodilator Therapy.
COPD is associated with nighttime respiratory symptoms, poor sleep quality, and increased risk of nocturnal death. Overnight deterioration of inspiratory capacity (IC) and FEV1 have been documented previously. However, the precise nature of this deterioration and mechanisms by which evening bronchodilation may mitigate this occurrence have not been studied. ⋯ Respiratory mechanics significantly deteriorated at night during placebo. Although the morning trough IC was unchanged, evening bronchodilator treatment was associated consistently with sustained overnight improvements in dynamic respiratory mechanics and inspiratory neural drive compared with placebo CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT02429765.
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Randomized Controlled Trial
A behaviour change intervention aimed at increasing physical activity improves clinical control in adults with asthma: a randomised controlled trial.
Higher levels of physical activity have been associated with better asthma clinical control. ⋯ ClinicalTrials.gov; No.: NCT03705702; URL: www.clinicaltrials.gov.
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Randomized Controlled Trial
Survivors of intensive care with type 2 diabetes and the effect of shared care follow-up clinics: the SWEET-AS randomized controlled pilot study.
Follow-up clinics after ICU admission have demonstrated limited benefit. However, existing trials have evaluated heterogeneous cohorts and used physicians who had limited training in outpatient care. ⋯ Outcomes for ICU survivors with type 2 diabetes are poor. Because of low participation and high mortality, a larger trial of a shared-care follow-up clinic in this cohort, using the present design, does not appear feasible.