The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Feb 2016
Multicenter StudyTIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients.
Acute kidney injury (AKI) is an important complication in surgical patients. Existing biomarkers and clinical prediction models underestimate the risk for developing AKI. We recently reported data from two trials of 728 and 408 critically ill adult patients in whom urinary TIMP2•IGFBP7 (NephroCheck, Astute Medical) was used to identify patients at risk of developing AKI. Here we report a preplanned analysis of surgical patients from both trials to assess whether urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) accurately identify surgical patients at risk of developing AKI. ⋯ Prognostic study, level I.
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J Trauma Acute Care Surg · Feb 2016
ReviewA systematic review of the use of resuscitative endovascular balloon occlusion of the aorta in the management of hemorrhagic shock.
Torso hemorrhage remains a leading cause of potentially preventable death within trauma, acute care, vascular, and obstetric practice. A proportion of patients exsanguinate before hemorrhage control. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an adjunct designed to sustain the circulation until definitive hemostasis. A systematic review was conducted to characterize the current clinical use of REBOA and its effect on hemodynamic profile and mortality. ⋯ Systematic review, level IV.
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J Trauma Acute Care Surg · Feb 2016
Randomized Controlled TrialThe incidence of ARDS and associated mortality in severe TBI using the Berlin definition.
The incidence of adult respiratory distress syndrome (ARDS) in severe traumatic brain injury (TBI) is poorly reported. Recently, a new definition for ARDS was proposed, the Berlin definition. The percentage of patients represented by TBI in the Berlin criteria study is limited. This study describes the incidence and associated mortality of ARDS in TBI patients. ⋯ Epidemiologic study, level II.
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J Trauma Acute Care Surg · Feb 2016
Use of endotracheal tubes with subglottic secretion drainage reduces ventilator-associated pneumonia in trauma patients.
Patients sustaining traumatic injuries have a higher incidence of ventilator-associated pneumonia (VAP) compared with other critically ill patient populations. Previous studies of patients with predominantly medical diagnoses and use of endotracheal tubes allowing subglottic secretion drainage (ETT-SSD) have shown significant reduction in VAP rates. We hypothesized that the use of ETT-SSD would reduce VAP in trauma patients. ⋯ Therapeutic/care management study, level III.
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J Trauma Acute Care Surg · Feb 2016
Controlled Clinical TrialA prospective, controlled clinical evaluation of surgical stabilization of severe rib fractures.
Previous studies of surgical stabilization of rib fractures (SSRF) have been limited by small sample sizes, retrospective methodology, and inclusion of only patients with flail chest. We performed a prospective, controlled evaluation of SSRF as compared with optimal medical management for severe rib fracture patterns among critically ill trauma patients. We hypothesized that SSRF improves acute outcomes. ⋯ Therapeutic study, level II.