Postgraduate medical journal
-
Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of methohexitone and propofol ('Diprivan') for induction of enflurane anaesthesia in outpatients.
In 73 unpremedicated patients scheduled for minor outpatient oral surgery or restorative dentistry, enflurane anaesthesia was induced either with an emulsion formulation of propofol (2.5 mg/kg) or with methohexitone (2 mg/kg). Sensations at the site of the injection were more common when the drugs were injected into a vein in the dorsum of the hand (58% for propofol and 28% for methohexitone) when compared to a vein in the forearm or antecubital area (7 to 8% with sensations). After induction of anaesthesia intravenous suxamethonium was given, and endotracheal intubation carried out. ⋯ The incidence of nausea or vomiting was similar (27 to 33%) in both groups. It is concluded that both propofol in emulsion form and methohexitone are satisfactory induction agents in outpatient dentistry. Propofol provided a smoother induction of anaesthesia and recovery was as rapid as after anaesthesia induced with methohexitone.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Cumulative experience with propofol ('Diprivan') as an agent for the induction and maintenance of anaesthesia.
In 60 unpremedicated patients, anaesthesia induction time decreased when the time taken to inject a bolus of 2 mg/kg propofol was decreased from 60 s to 5 s. Apnoea at induction was noted in all groups but the degree of cardiorespiratory depression was not influenced by the rate of injection. ⋯ In comparison with thiopentone 4 mg/kg, propofol produced a greater degree of arterial hypotension and a smaller increase in heart rate. Preliminary results with an infusion of propofol for maintenance of anaesthesia suggest that rapid recovery can be achieved after operations of long duration.