Postgraduate medical journal
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This study aimed to investigate the association of the fibrinogen-to-albumin ratio (FAR) and all-cause mortality as well as cardiovascular mortality in patients on dialysis with acute coronary syndrome (ACS). Furthermore, we explored the incremental prognostic value of incorporating the FAR into the Global Registry of Acute Coronary Events (GRACE) score. ⋯ In patients on dialysis with ACS, the FAR was independently associated with increased risks of all-cause mortality and cardiovascular mortality. Incorporating the FAR might improve the predictive accuracy of the GRACE score in patients on dialysis with ACS.
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To compare the efficacy of two one-handed face mask ventilation techniques. Secondarily, we also assessed the effect of hand size on the performance of both these techniques. ⋯ On the simulation model, compared to the one-handed EC face mask ventilation technique, the EO technique is more conducive to the learning and mastery of novices and small-handed operators.
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This study aimed to explore the causal association between sleep duration and depression in adolescents and young adults. ⋯ Sleep duration was causally associated with depression in adolescents and young adults. Sleep duration of <6 h or >8 h daily increases the depression risk in adolescents and young adults.
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Genetically predicted basal metabolic rate and infectious diseases: a Mendelian randomization study.
The causal relationship between basal metabolic rate (BMR) and infectious diseases remains elusive. This study aims to clarify this association. ⋯ The study revealed a significant link between increased BMR and elevated risks of SSTIs, osteomyelitis, and bacterial infections, highlighting the intricate BMR-immune connection and its implications for disease control. Key message What is already known on this topic: High BMR is positively correlated with COVID-19 and associated with proinflammatory and immunological activation, but the relationship between BMR and other infectious diseases remains largely unexplored. What this study adds: Higher BMR significantly raises the risk of SSTIs, osteomyelitis, all-cause infections, and sepsis. VAT, HbA1c, CRP, and BMI may mediate the BMR-infection relationship. How this study might affect research, practice, or policy: A higher BMR may be a valuable indicator associated with an increased risk for SSTIs, osteomyelitis, and sepsis. Modulating BMR might hold promise as a clinically relevant intervention to prevent specific infectious diseases.