Computers in biology and medicine
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Heart rate complexity (HRC) is a proven metric for gaining insight into human stress and physiological deterioration. To calculate HRC, the detection of the exact instance of when the heart beats, the R-peak, is necessary. Electrocardiogram (ECG) signals can often be corrupted by environmental noise (e.g., from electromagnetic interference, movement artifacts), which can potentially alter the HRC measurement, producing erroneous inputs which feed into decision support models. ⋯ This raises many questions regarding how this fiducial point is altered by noise, the resulting impact on the measured HRC, and how we can account for noisy HRC measures as inputs into our decision models. This work uses Monte Carlo simulations to systematically add white and pink noise at different permutations of signal-to-noise ratios (SNRs), time segments, sampling rates, and HRC measurements to characterize the influence of noise on the HRC measure by altering the fiducial point of the R-peak. Using the generated information from these simulations provides improved decision processes for system design which address key concerns such as permutation entropy being a more precise, reliable, less biased, and more sensitive measurement for HRC than sample and approximate entropy.
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A novel computer-aided detection (CAD) scheme for lung nodule detection using a 3D deep convolutional neural network combined with a multi-scale prediction strategy is proposed to assist radiologists by providing a second opinion on accurate lung nodule detection, which is a crucial step in early diagnosis of lung cancer. ⋯ The experimental results demonstrate the outstanding detection performance of the proposed nodule detection scheme. In addition, the proposed scheme can be extended to other medical image recognition fields.