European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jan 1989
Randomized Controlled Trial Clinical TrialEffects of clobazam and clonazepam on saccadic eye movements and other parameters of psychomotor performance.
The effects of two benzodiazepine anticonvulsants clobazam (20 mg) and clonazepam (2 mg) in a variety of psychomotor performance tests were compared in a placebo controlled double-blind acute oral dose study in ten healthy volunteers. Assessments included critical flicker fusion (CFF) threshold, the Sternberg memory scanning and choice reaction time (CRT), peak saccadic velocity (PSV) and visual analogue scales, all previously shown to be sensitive to the effects of benzodiazepines. ⋯ Clonazepam significantly increased memory scanning time compared to clobazam. Clobazam was remarkably free of cognitive and psychomotor side-effects.
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Eur. J. Clin. Pharmacol. · Jan 1989
Inaccuracy in the doses of injectable medications dispensed from rubber-stoppered vials.
The literature of pharmacology often assumes that a full dosage is utilized when the contents of a vial have been administered by syringe. Five hundred discarded medication vials were assayed. The residues amounted to 1.98% to 8.81% of the listed dosages. ⋯ Although the amount of drug lost during preparation and administration may be of little therapeutic consequence, the discrepancy between intended and administered dosage is reflected in economic loss and pharmacological confusion. Pharmacological data should be adjusted for such losses. Medication wastage could be reduced by redesign of vials and alterations in practice of the administration.