European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jan 1989
Randomized Controlled Trial Clinical TrialEffects of clobazam and clonazepam on saccadic eye movements and other parameters of psychomotor performance.
The effects of two benzodiazepine anticonvulsants clobazam (20 mg) and clonazepam (2 mg) in a variety of psychomotor performance tests were compared in a placebo controlled double-blind acute oral dose study in ten healthy volunteers. Assessments included critical flicker fusion (CFF) threshold, the Sternberg memory scanning and choice reaction time (CRT), peak saccadic velocity (PSV) and visual analogue scales, all previously shown to be sensitive to the effects of benzodiazepines. ⋯ Clonazepam significantly increased memory scanning time compared to clobazam. Clobazam was remarkably free of cognitive and psychomotor side-effects.