European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jan 1997
Randomized Controlled Trial Multicenter Study Clinical TrialEvaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever.
We compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6-24 months in an open, randomised study with three parallel groups. ⋯ The efficacy of ibuprofen was better than that of aspirin or paracetamol. In spite of more adverse events, the comfort scores were significantly in favour of ibuprofen 6 h after the first dose of treatment.