Anesthesia and analgesia
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Anesthesia and analgesia · May 2008
Comparative StudyPropranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain.
Propranolol is a beta-adrenoceptor antagonist used clinically. Local anesthetics are used for controlling pain, whereas propranolol is concomitantly given to treat hypertension and tachycardia. However, there are few studies examining the effects of propranolol on the toxicity of local anesthetics. We investigated the effect of propranolol on lidocaine-induced convulsions in awake, spontaneously breathing rats. ⋯ Propranolol increased the threshold for lidocaine-induced convulsions by directly acting on the brain.