Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Nov 1997
Biography Historical Article[The Rokitansky morgue. Historical retrospect on the occasion of the anniversary years of Vienna pathology 1996 and 1997].
On the occasion of three anniversaries in 1996 and 1997 the historical background of the early pathology in Vienna is documented. 1796 Aloys Rudolph Vetter became the first official prosector of the "Allgemeines Krankenhaus". Since 1817, i.e., 180 years ago, continuously autopsy reports were documented, written by Rokitansky, Kundrat, Kolisko, Weichselbaum and the discoverer of blood groups Landsteiner. 1827 november 1st, Carl Rokitansky entered the old "Leichenhaus" as a practitioner without academic degree. Of this house exist three different pictures, only one of them is an authentic photograph, the others are drawings. This rare original photograph of the working room from the beginning of Viennese pathology is first published in medical literature in honour to the long tradition of autopsy-performing pathology.
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Wien. Klin. Wochenschr. · Oct 1997
Clinical Trial Controlled Clinical Trial[Intrathecal administration of triamcinolone in treatment of pain after discectomy].
The efficacy and compatibility of intrathecal corticoid therapy was studied in a series of 160 patients (out of a total collective of 3000 patients operated on over a 5-year period for disc herniation) suffering from continuing pain in the first 5 days following discectomy. 80 patients received triamcinolone acetonide in crystalline suspension (Volon A 80, 2.0 ml) intrathecally via lumbar puncture on the 5th postoperative day (group A). The remaining 80 patients acted as controls (group B). Additionally, all patients were treated by conservative means. ⋯ However, in 11 cases (13%) postpunctional signs of greater or lesser severity, reaching from slight to severe headache with nausea and vomiting occurred. All these symptoms disappeared at the latest within 1 week and would--in our opinion--be avoidable by correct lumbar puncture technique. In general, this study revealed that intrathecal triamcinolone administration is highly effective in the relief of postdiscectomy pain and may reduce the period of postoperative pain significantly.
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Wien. Klin. Wochenschr. · Sep 1997
Multicenter Study Clinical TrialPhase II trial of gemcitabine in advanced non-small-cell lung cancer.
Gemcitabine has shown activity in different solid tumors. In the present study we have evaluated its efficacy in 32 patients with advanced non-small-cell lung cancer in a phase II trial. Gemcitabine (1250 mg/m2) was given intravenously as a 30-minute infusion on days 1, 8 and 15. ⋯ Improvement of symptoms occurred in 54% of the patients. Side effects were mild and included predominantly leukopenia and thrombocytopenia. In conclusion, gemcitabine is active and well tolerated in patients with advanced non-small-cell lung cancer.
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Wien. Klin. Wochenschr. · Aug 1997
Mycoplasma hominis and Ureaplasma urealyticum in patients with sexually transmitted diseases.
Mycoplasma hominis and Ureaplasma urealyticum can be isolated with considerable frequency from the human urogenital tract and are thought to cause various syndromes such as nongonococcal urethritis, pelvic inflammatory disease, pyelonephritis or infertility. The aim of this study was the evaluation of the presence of different genital pathogens in patients with sexually transmitted diseases (STD) and, in particular, the detection of mycoplasmas in individuals infected with genital microbes and an assessment of the presence of genital microorganisms in patients harbouring Mycoplasma hominis or Ureaplasma urealyticum. Furthermore, the occurrence of mycoplasmas in women with bacterial vaginosis was established. ⋯ In both men and women, trichomoniasis increased colonisation with Mycoplasma hominis, while mycoplasmas occurred less frequently together with genital candidiasis. Mycoplasma hominis was cultivated significantly more often in women with bacterial vaginosis than in those without. In contrast to urethral infections in men, cervical infections with Neisseria gonorrhoeae or Chlamydia trachomatis raised the incidence of Mycoplasma hominis in the vaginal fluid.
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Wien. Klin. Wochenschr. · May 1997
Review[Systemic inflammatory reactions to extracorporeal therapy measures (II): Cardiopulmonary bypass].
About 65,000 cardiac patients undergo surgery annually in Germany with the assistance of cardiopulmonary bypass. The "post pump inflammatory response" (the systemic and myocardial inflammatory response syndrome post cardiac surgery), triggered at least in part by the cardiopulmonary bypass, contributes substantially towards morbidity (e.g., myocardial depression) and mortality in these patients. ⋯ Scoring systems and measurements of tumor necrosis factor-alpha, as well as soluble tumor necrosis factor receptors, allow the early detection of an "escalating inflammatory response" in 2-10% of all patients, which is associated with a worse prognosis. Therapeutic attempts to suppress these systemic and myocardial inflammatory reactions focus on blockade of the complement system, coating of CPB membranes with heparin, leucocyte depletion and attenuation of leucocyte function, elimination of toxins and mediators by means of hemofiltration, as well as on the administration of antiproteases, antioxidants, oxygen radical scavengers and also of immune globulins.