European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 2022
Major bleeding in patients with pulmonary embolism presenting with syncope.
Syncope has been shown to be a risk factor of bleeding in patients receiving thrombolytic therapy for acute pulmonary embolism (PE). Whether syncope predicts bleeding in a broader population of patients with PE remains unknown. ⋯ Syncope is a predictor of major bleeding events in patients with PE, even among those receiving anticoagulation monotherapy.
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Eur. J. Clin. Invest. · Jul 2022
ReviewA comprehensive review of adverse events to drugs used in COVID-19 patients: Recent clinical evidence.
Since the breakthrough of the pandemic, several drugs have been used to treat COVID-19 patients. This review aims to gather information on adverse events (AE) related to most drugs used in this context. ⋯ Some SOCs seem to be more frequent than others among the COVID-19 drugs included, although neither of the studies included reported causality analysis. For that purpose, further clinical studies with robust methodologies, as randomised controlled trials, should be designed and performed.
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Eur. J. Clin. Invest. · Jul 2022
Serum potassium level, variability and in-hospital mortality in acute myocardial infarction.
Clinical guidelines recommend an optimal serum potassium concentration between 4.0 and 5.0 mmol/L in patients with acute myocardial infarction (AMI), which was based on lower-quality evidence from more than 20 years ago. Therefore, it is essential to re-evaluate the range of optimal potassium levels in patients with AMI in intensive care unit (ICU). ⋯ Among AMI patients in ICU, the minimum risk of in-hospital mortality was observed in those with mean potassium levels between 3.5 and 4.5 mmol/L or a minimal potassium variability compared to those who had higher or lower values.
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Eur. J. Clin. Invest. · Jul 2022
Impaired fibrin clot lysis is associated with increased mortality in patients after coronary artery bypass grafting: a long-term follow-up study.
Mortality after coronary artery bypass grafting (CABG) is primarily thromboembolic by nature. We investigated whether impaired fibrinolysis observed in cardiovascular diseases is associated with long-term mortality following CABG. ⋯ In this study, we showed that reduced fibrin clot susceptibility to fibrinolysis is weekly associated with long-term mortality in advanced CAD.
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Eur. J. Clin. Invest. · Jul 2022
Association between cardiorespiratory fitness and risk of all-cause and cause-specific mortality.
The association of cardiorespiratory fitness (CRF) with all-cause and cause-specific mortality remains unclear in Chinese population. This study aimed to evaluate the risk of all-cause, cardiovascular disease (CVD), cancer and other-cause mortality in Chinese adults using estimated CRF (eCRF). ⋯ eCRF was inversely associated with all-cause, CVD and other-cause mortality.