European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 1993
Randomized Controlled Trial Clinical TrialRelationship between ventilation and carbon dioxide production in normal subjects with induced changes in anatomical dead space.
The aim of this study was to test the hypothesis that the increased ventilation to carbon dioxide production relationship on exercise associated with chronic cardiac failure may be due in part to changes in respiratory pattern, causing an increase in anatomical dead space ventilation. In order to assess the effect of changes in respiratory pattern on the relationship between ventilation and carbon dioxide production, normal subjects exercised at the same level at three different respiratory rates (normal, 25% slower, 25% faster). ⋯ There were no significant changes in ventilation, carbon dioxide production, or the correlation between ventilation and carbon dioxide production. This finding lends support to the view that changes in respiratory pattern can only be responsible for a very small proportion of the VE/VCO2 slope difference between chronic cardiac failure and normals.
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Eur. J. Clin. Invest. · Oct 1992
Randomized Controlled Trial Clinical TrialThe effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial.
To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis. ⋯ Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.