European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 2021
Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells.
Ferroptosis is an iron-dependent and oxidative cell death form. Recent studies suggested that circular RNAs (circRNAs) regulated ferroptosis in tumour cells. Circ_0007142 was identified as a carcinogenic molecule in colorectal cancer (CRC), but its function on ferroptosis in CRC remains unknown. ⋯ All these findings proved that circ_0007142/miR-874-3p/GDPD5 axis regulated tumorigenesis and ferroptosis of CRC cells. Circ_0007142 might be an available marker for ferroptosis in CRC therapy.
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Eur. J. Clin. Invest. · Jun 2021
Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement.
Arterial tortuosity is linked to a higher risk of adverse clinical events after transfemoral transcatheter aortic valve replacement (TF-TAVR). Currently, there are no assessment tools that can quantify this variable in three-dimensional space. This study investigated the impact of novel scoring methods of iliofemoral tortuosity on access and bleeding complications after TF-TAVR. ⋯ Vascular tortuosity is an underestimated risk factor during TF-TAVR. The IFT score is a valuable tool in risk stratification before TF-TAVR, predicting periprocedural access and bleeding complications.
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Eur. J. Clin. Invest. · Jun 2021
ReviewIntegrated Care and Outcomes in Patients with Atrial Fibrillation and Comorbidities.
Integrated care for management of atrial fibrillation (AF) patients has been associated with a reduction in adverse events. The 'Atrial fibrillation Better Care (ABC) pathway' has been proposed to streamline such integrated management. In this paper, we analysed the impact of ABC pathway adherent clinical management on outcomes in AF patients with high-risk 'metabolic' comorbidities (i.e. diabetes mellitus [DM], chronic kidney disease [CKD], metabolic syndrome [MetS]. ⋯ In high-risk AF patients with DM, CKD and MetS, ABC pathway adherent management was associated with a lowered risk of the composite outcome of cardiovascular events, cardiovascular and all-cause death.
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Eur. J. Clin. Invest. · Jun 2021
Meta AnalysisBMI and Atrial Fibrillation Recurrence Post Catheter Ablation: A Dose-Response Meta-analysis.
The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. ⋯ CRD42020198787.