European journal of clinical investigation
-
Eur. J. Clin. Invest. · Apr 2021
Myeloperoxidase and CYBA genetic variants in polycystic ovary syndrome.
Oxidative stress plays a pivotal role in the pathogenesis of polycystic ovary syndrome (PCOS). Genetic variations in myeloperoxidase (MPO; G-463A) and NADPH oxidase p22phox subunit (CYBA; C242T) cause inter-individual variability in enzyme activities. Here, we investigated the associations between MPO activity and the MPO G-463A and CYBA C242T polymorphisms in Chinese women with PCOS. ⋯ The MPO G-463A variant, but not CYBA C242T variant, is associated with a risk of PCOS in Chinese women.
-
Eur. J. Clin. Invest. · Apr 2021
Characterization of Gut Microbiota in Polycystic Ovary Syndrome: Findings from a Lean Population.
Limited available animal and human data suggest an association between dysbiosis of gut microbiota and PCOS. We aimed to determine whether gut microbiota in lean women with PCOS shows any alterations compared to healthy women. ⋯ Our results suggest that gut microbiome of lean PCOS patients with full phenotype shows compositional alterations with similar bacterial richness and diversity compared to controls and that hyperandrogenism is associated with dysbiosis.
-
Eur. J. Clin. Invest. · Apr 2021
Associated factors of co-existent pulmonary tuberculosis and lung cancer: a case-control study.
Although the incidence of co-existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co-existent PTB and lung cancer (PTB-lung cancer) cases in a case-control study. ⋯ Distinct clinical symptoms and CT tests may help with the early diagnosis of PTB-lung cancer cases. PTB patients with fibrous calcification may have a higher risk of lung cancer. Further multicenter prospective studies are required to validate our findings.
-
Eur. J. Clin. Invest. · Mar 2021
Physical activity may not be associated with long-term risk of dementia and Alzheimer's disease.
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD). ⋯ In middle-aged Caucasian men, various physical activity exposures were not associated with all-cause dementia or AD. Future studies should address biases due to reverse causation and regression dilution and should involve objective measures of physical activity.