European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2020
Randomized Controlled TrialNon-specific analgesia during a clinical trial in fibromyalgia.
When patients suffering from fibromyalgia undergo a therapeutic trial, a non-negligible part of analgesia is not explained by the drug itself. The mechanisms of this non-specific effect need to be understood. ⋯ The changes observed concomitantly to non-specific pain analgesia might be related to mild changes in brain functioning, based on convergent literature data.
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Eur. J. Clin. Invest. · Nov 2020
ReviewInvestigating the Capabilities of Information Technologies to support Policymaking in COVID-19 Crisis Management; A Systematic Review and Expert opinions.
Today, numerous countries are fighting to protect themselves against the Covid-19 crisis, while the policymakers are confounded and empty handed in dealing with this chaotic circumstance. The infection and its impacts have made it difficult to make optimal and suitable decisions. New information technologies play significant roles in such critical situations to address and relieve stress during the coronavirus crisis. This article endeavours to recognize the challenges policymakers have typically experienced during pandemic diseases, including Covid-19, and, accordingly, new information technology capabilities to encounter with them. ⋯ The results illustrate that the challenges fall into two categories including; encountering the disease and reducing the results of the disease. Furthermore, Internet of things, cloud computing, machine learning and social networking play the most significant roles to address these challenges.
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Eur. J. Clin. Invest. · Nov 2020
Observational StudyTicagrelor and prasugrel are independent predictors of improved long-term survival in ACS patients.
To investigate the long-term clinical benefit of dual antiplatelet therapy with potent P2Y12 inhibitors compared to clopidogrel in patients with acute coronary syndrome (ACS). ⋯ In the setting of ACS, treatment with ticagrelor or prasugrel reduced long-term mortality and 1-year MACE as compared to clopidogrel.
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Eur. J. Clin. Invest. · Nov 2020
Biological senescence risk score. A practical tool to predict biological senescence status.
Ageing and biological senescence, both related to cardiovascular disease, are mediated by oxidative stress and inflammation. We aim to develop a predictive tool to evaluate the degree of biological senescence in coronary patients. ⋯ These predictive models allow us to calculate the degree of biological senescence in coronary patients, identifying a subgroup of patients at higher risk and who may require more intensive treatment.
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Eur. J. Clin. Invest. · Nov 2020
Observational StudyBariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity.
There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases. ⋯ For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.