European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2020
A Mendelian Randomization Analysis: The Causal Association Between Serum Uric Acid and Atrial Fibrillation.
Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis using genetic instrumental variables (IVs). ⋯ The serum UA level was independently associated with the AF risk.
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Eur. J. Clin. Invest. · Oct 2020
Sociodemographic factors, current asthma and lung function in an urban child population.
We aimed to assess which sociodemographic factors are associated with current asthma and indicators of lung function in 10-year-old children. ⋯ Among 10-year-old children, ethnic background was associated with current asthma and lung function after adjusting for a wide range of sociodemographic factors. No associations were found between socioeconomic status indicators and current asthma. Explanations for these associations such as language barriers, suboptimal care or pathophysiological differences require further investigation.
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Eur. J. Clin. Invest. · Sep 2020
ReviewBasic Immunology may lead to translational therapeutic rationale:: SARS-CoV-2 and Rheumatic Diseases.
COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. ⋯ Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS-CoV-2 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI).