European journal of clinical investigation
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Eur. J. Clin. Invest. · May 2020
Systemic transsulfuration pathway thiol concentrations in chronic obstructive pulmonary disease patients.
It is amply reported that patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular disease (CVD). Recent evidence suggests that COPD patients have elevated concentrations of plasma homocysteine (Hcy), a transsulfuration pathway analyte that is commonly regarded as a CVD risk factor. ⋯ Both total Hcy and CysGly concentrations were significantly associated with the presence and severity of COPD and with markers of oxidative stress (total CysGly) and inflammation (total Hcy and CysGly). This suggests that specific low molecular mass thiols might play a role in the inflammatory and oxidative stress pathways involved in both CVD and COPD.
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Eur. J. Clin. Invest. · May 2020
Fibrinogen/Albumin ratio: A more powerful prognostic index for patients with end-stage renal disease.
Microinflammation is linked to an increased risk of death due to cardiovascular disease (CVD) in patients with end-stage renal disease (ESRD). Although the fibrinogen/albumin ratio (FAR), a novel inflammatory marker, has been shown to predict mortality in various diseases, limited evidence is available for its role in ESRD. The purpose of this study is to explore the prognostic value of the FAR in ESRD patients on peritoneal dialysis (PD). ⋯ Our results suggest that a high baseline FAR value is an independent prognostic factor in ESRD patients on PD.
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Eur. J. Clin. Invest. · May 2020
Hypocalcaemia predicts 12-month re-hospitalization in heart failure.
Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12-month clinical outcome in the disease. ⋯ Baseline hypocalcaemia predicted 12-month cardiac re-hospitalization and death in HFpEF patients without calcium and vitamin D supplements partly through left ventricle and skeletal muscle function pathways.
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Eur. J. Clin. Invest. · May 2020
Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease.
This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. ⋯ SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.