European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2015
Meta AnalysisEffect of vitamins C and E on insulin resistance in diabetes: a meta-analysis study.
Data regarding the effect of vitamin C (VC) and vitamin E (VE) supplementation on insulin resistance in type 2 diabetes mellitus (T2DM) are controversial. We aimed to systematically review the current data on this topic. ⋯ The sole intake of VC, VE or their combination with other antioxidants could not improve insulin resistance in diabetes.
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Eur. J. Clin. Invest. · Nov 2015
ReviewAdipose tissue and metabolic syndrome: too much, too little or neither.
Obesity is strongly associated with metabolic syndrome. Recent research suggests that excess adipose tissue plays an important role in development of the syndrome. On the other hand, persons with a deficiency of adipose tissue (e.g. lipodystrophy) also manifest the metabolic syndrome. ⋯ Another mechanism whereby adipose tissue could worsen the metabolic syndrome is through release of adipokines. This is an intriguing mechanism, but the impact of adipokines on metabolic syndrome risk factors is uncertain. Thus, many potential connections between adipose tissue and metabolic syndrome remain to unravelled.
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Eur. J. Clin. Invest. · Nov 2015
Tissue Doppler Imaging predicts central sleep apnea in patients with chronic heart failure: data from the Daunia Registry.
Tissue Doppler imaging (TDI) is used to improve risk stratification in patients with chronic heart failure (CHF). So far, few studies have used this method to investigate the characteristics of subjects with CHF and Cheyne-Stokes breathing (CSB). The aim of this study was therefore to evaluate whether TDI assessment may predict the presence of CSB in patients with CHF. ⋯ Tissue Doppler imaging values (A') are associated with the presence of sleep apnea at nocturnal polygraphy.
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Eur. J. Clin. Invest. · Oct 2015
Polymorphisms in CYP-mediated arachidonic acid routes affect the outcome of renal transplantation.
Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP) enzymes to vasoactive metabolites (mainly epoxyeicosatrienoic acids) which are known to play a protective role against damaging processes that may occur after re-oxygenation of the graft. We aimed to investigate whether the presence of functional polymorphisms along these metabolic routes may play a role in the outcome of renal transplantation. ⋯ Taken together, these results indicate that variability in the CYP450 genes involved in the synthesis of eicosanoids from AA may have a significant impact on graft function and survival in renal transplantation.
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Eur. J. Clin. Invest. · Oct 2015
Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population.
Regular physical activity is recommended to lower low-density lipoprotein cholesterol (LDL-C) in a healthy population. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) was shown to reduce (LDL-C) levels; however, the impact of physical exercise on PCSK9 levels remains unclear. ⋯ Daily physical activity at the work place is independently associated with a decrease in PCSK9 levels over time.