European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2013
Stress hyperglycaemia in hospitalized patients with coronary artery disease and type 2 diabetes risk.
⋯ We reported a high prevalence of AGR in subjects with CAD. Stress hyperglycaemia in patients with CAD was not associated with an increased risk of diabetes 3 months later. HbA1c in patients hospitalized with CAD was a useful tool to detect AGR.
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Eur. J. Clin. Invest. · Oct 2013
Comparative StudyNon-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study.
There is an ongoing debate about the performance of non-high-density lipoprotein cholesterol (non-HDL-C) compared with apolipoprotein B (apo B) in the prediction of coronary heart disease (CHD) risk. Therefore, we compared the associations between non-HDL-C and apo B in regard to CHD among apparently healthy Western European individuals. ⋯ In this prospective study, non-HDL-C and apo B were comparable in their ability to predict risk of future CHD.
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Eur. J. Clin. Invest. · Oct 2013
Clinical and genetic characteristics of Chinese patients with hereditary haemorrhagic telangiectasia-associated pulmonary hypertension.
Mutations in activin receptor-like kinase-1 (ACVRL-1) or endoglin (ENG) are mostly identified in patients with hereditary haemorrhagic telangiectasia (HHT) associated with pulmonary hypertension (PH), but have not yet been studied in Chinese patients. ⋯ Our findings have revealed the clinical phenotype and molecular genetic features of HHT-associated PH in Chinese Han patients and indicate that mutations of ACVRL-1 and ENG are genetic predisposing factors in Chinese patients. Our data further addressed clinical management and have provided limited experience in treating this group of disorders.
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Eur. J. Clin. Invest. · Sep 2013
Multicenter StudyIncidence and prognosis of dysnatraemia in critically ill patients: analysis of a large prevalence study.
The objective of this study is to assess the impact of dysnatraemia on mortality among intensive care unit (ICU) patients in a large, international cohort. ⋯ Dysnatraemia is more frequent during the ICU stay than on the day of admission. Dysnatraemia in the ICU - even mild - is an independent predictor of increased hospital mortality.
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Eur. J. Clin. Invest. · Sep 2013
ReviewPathophysiological role of the renin-angiotensin system on erectile dysfunction.
The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionally, we update evidence on recent findings on the role of the Ang-(1-7) and Mas receptor on the erectile function and its therapeutic potential for treating erectile dysfunction (ED). ⋯ Ang-(1-7) and Mas receptor pathway might be considered as a promising therapeutic target for the treatment of ED.