European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 1993
Randomized Controlled Trial Clinical TrialRelationship between ventilation and carbon dioxide production in normal subjects with induced changes in anatomical dead space.
The aim of this study was to test the hypothesis that the increased ventilation to carbon dioxide production relationship on exercise associated with chronic cardiac failure may be due in part to changes in respiratory pattern, causing an increase in anatomical dead space ventilation. In order to assess the effect of changes in respiratory pattern on the relationship between ventilation and carbon dioxide production, normal subjects exercised at the same level at three different respiratory rates (normal, 25% slower, 25% faster). ⋯ There were no significant changes in ventilation, carbon dioxide production, or the correlation between ventilation and carbon dioxide production. This finding lends support to the view that changes in respiratory pattern can only be responsible for a very small proportion of the VE/VCO2 slope difference between chronic cardiac failure and normals.
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Eur. J. Clin. Invest. · Nov 1992
Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma.
To further investigate if the pulmonary surfactant system is altered in acute parenchymal lung injury of adults following polytrauma we measured SP-A level and phospholipid composition in 150 sequentially obtained lung lavage samples from poly-traumatized patients (n = 19) beginning at the day of trauma and ending 18 days later or when the patient was extubated. Out of the 19 patients studied 10 had severe parenchymal lung injury (ARDS), nine had moderate lung injury. SP-A was measured using a two-monoclonal sandwich ELISA-assay. ⋯ In patients who had moderate lung injury the SP-A level normalized, but in patients who had severe lung injury the SP-A level remained low during the timespan examined. SP-A alterations did not correlate to changes in phospholipid composition as determined in lung lavage samples of individual patients. We conclude that alveolar SP-A concentrations decrease in polytraumatized patients who have acute parenchymal lung injury soon after the trauma occurs.(ABSTRACT TRUNCATED AT 250 WORDS)
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Eur. J. Clin. Invest. · Oct 1992
Randomized Controlled Trial Clinical TrialThe effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial.
To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis. ⋯ Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.
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Eur. J. Clin. Invest. · Jun 1991
High blood pressure and insulin resistance: influence of ethnic background.
Hyperinsulinaemia links non-insulin dependent diabetes (NIDDM), obesity, and hypertension, each an insulin-resistant state in its own right. Insulin resistance predicts the occurrence of NIDDM, and plays a major role in its pathogenesis. We tested the hypothesis that hyperinsulinaemia may also predict hypertension in a sample (n = 2905) of the mixed population of San Antonio, in which hyperinsulinaemia and NIDDM are more prevalent among Mexican-Americans than non-Hispanic whites. ⋯ Post-glucose plasma glucose levels also were directly related to hypertension prevalence in both groups; again, the regression line was shifted downward and, furthermore, less steep (P less than 0.02) in Mexican-Americans, suggesting relative protection against the negative effect of hyperglycaemia on blood pressure. Dyslipidaemia (higher total cholesterol and triglyceride, and lower HDL-cholesterol concentrations) was strongly associated with hyperinsulinaemia and blood pressure in both ethnic groups. After adjusting for plasma insulin, only hypertriglyceridaemia was associated with high blood pressure, with no inter-ethnic difference.(ABSTRACT TRUNCATED AT 250 WORDS)