European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2025
Trends and disparities in atrial fibrillation-related mortality among adults with co-morbid diabetes mellitus in the United States.
From 1999 to 2020, age-adjusted mortality rates (AAMR) for atrial fibrillation-related deaths among U. S. adults (age ≥25) with comorbid diabetes mellitus increased significantly with an annual percent change of 6.5%. The highest mortality rates were observed in males, older adults, non-Hispanic Whites, and residents of urban areas and the West region, underscoring the urgent need for targeted public health strategies.
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Eur. J. Clin. Invest. · Jan 2025
The use of the Crohn's disease exclusion diet (CDED) in adults with Crohn's disease: A randomized controlled trial.
The Crohn's disease exclusion diet (CDED) has been shown to induce remission in adult Crohn's disease (CD) patients. The aim of the study is to provide additional evidence-based validation. ⋯ The CDED was effective in inducing remission among patients with mild-to-moderate CD and appeared to be safe and well-accepted.
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Eur. J. Clin. Invest. · Jan 2025
ReviewImaging predictors of adverse prognosis in Fabry disease cardiomyopathy: A systematic review and meta-analysis.
Cardiac involvement represents the main cause of death in patients with Fabry disease (FD). Echocardiography and cardiovascular magnetic resonance (CMR) have an established diagnostic role, but their prognostic value remains unresolved. This systematic review and meta-analysis sought to assess the prognostic implications of imaging parameters in FD. ⋯ Several imaging parameters were significant predictors of adverse clinical outcomes in patients with FD. Late gadolinium enhancement showed the strongest association with adverse prognosis.
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Eur. J. Clin. Invest. · Jan 2025
Altered fibrin clot properties and elevated von Willebrand factor are associated with progression to permanent atrial fibrillation: A cohort study.
The role of a prothrombotic state in atrial fibrillation (AF) progression to permanent arrythmia (PerAF) is unclear. Formation of denser and poorly lysable fibrin clots has been observed in AF patients also with sinus rhythm in association with higher stroke risk. We investigated whether altered fibrin clot properties and other prothrombotic state markers may contribute to AF transition to PerAF. ⋯ Suppressed fibrin clot susceptibility to lysis and elevated vWF could contribute to progression to PerAF despite anticoagulation, which suggests links between blood coagulation and AF progression.