Medicine
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This study used network meta-analysis to compare the effects of various exercise interventions, with the aim of identifying the most effective intervention measures. ⋯ The majority of exercise interventions demonstrated a discernible impact on the QoL in women following breast cancer surgery. The effects of diverse exercise interventions on the 3 QoL outcome indicators in patients with breast cancer exhibited variability. However, irrespective of the QoL measurement technique used, aerobic and resistance exercise continue to be the most favorable choices.
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Review Case Reports
Lamotrigine associated extensive hyperpigmentation: A case report and literature review.
Lamotrigine (LTG)-associated extensive hyperpigmentation is rare and may persist for a long time or even become permanent. LTG-associated cutaneous adverse reaction (CAR) manifests initially as mild maculopapular exanthema (MPE). The first step in CAR therapy is to immediately discontinue the offending LTG for predicting evolution to mild or severe forms not always possible. Here, we present a rare case of LTG-associated extensive hyperpigmentation for delaying the withdrawal of LTG. ⋯ This case suggests that LTG may cause not only MPE but also extensive hyperpigmentation. When a patient displays a mild MPE following the initiation of LTG in the outpatient clinic, LTG-associated CAR should not be overlooked as a diagnosis, and early withdrawal of LTG should be considered at first.
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Review Case Reports
Identification of a novel TSC1 variant in a family with developmental and epileptic encephalopathies: A case report and literature review.
Tuberous sclerosis (TSC) is an autosomal dominant neurocutaneous syndrome resulting from mutations in the tumor suppressor genes TSC1 and TSC2. Unfortunately, the absence of accurate diagnosis has significantly impacted the well-being of both patients and their families. Furthermore, the pathogenicity of numerous variants remains unverified, which could potentially result in misinterpretation of their functional implications. ⋯ This finding strengthens the significant phenotypic variability associated with TSC and expands the mutational spectrum of this rare disease.
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Meta Analysis
Prevalence of swallowing disorder among older adults in nursing homes: A meta-analysis.
To determine the prevalence of swallowing disorders in nursing homes and to analyze the prevalence in China and abroad. Providing basis for intervention, treatment, and care for swallowing disorders in elderly residents of nursing homes. ⋯ The high prevalence of swallowing disorders in nursing homes (33.2%) identified in this study underscores the need for greater attention to screening, diagnosis, and intervention strategies.
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Meta Analysis
Investigating the link between coronary artery calcification and atrial fibrillation: A systematic review and meta-analysis.
Both coronary artery calcification (CAC) and atrial fibrillation (AF) are associated with common risk factors, such as age, hypertension, diabetes, and dyslipidemia. Investigating their association may provide insights into shared pathophysiological mechanisms and overlapping risk profiles. ⋯ It can be concluded that there is a robust and consistent association between CAC and AF. Our systematic review underscores the importance of considering CAC as a potential factor in assessing the risk of AF, while also recognizing the multifactorial nature of this relationship.