Clinical neurology and neurosurgery
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Clin Neurol Neurosurg · Jun 2005
ReviewTreatment of motor dysfunction in Parkinson's disease: an overview.
Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. ⋯ Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
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Clin Neurol Neurosurg · Jun 2005
Functional outcome of intrathecal baclofen administration for severe spasticity.
To estimate the functional benefit in patients with severe spasticity treated with intrathecal baclofen infusion through an implantable pump and to stress the need for functional assessment of these patients with a functional scale. ⋯ Reduction of spasticity and spasms achieved with intrathecally delivered baclofen, leads to functional improvement and pain relief.