Clinical neurology and neurosurgery
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Clin Neurol Neurosurg · Oct 2013
Comparative StudyA comparison between cyberknife and neurosurgery in solitary brain metastases from non-small cell lung cancer.
To evaluate the efficacy of cyberknife (CK) and neurosurgery (NS) in patients newly diagnosed as solitary brain metastasis (SBM) from non-small cell lung cancer (NSCLC). ⋯ There was no statistical difference between CK and NS for SBM from NSCLC in OS, LC and IC. However, CK is less invasive and may be more acceptable for patients. The result needs randomized trials to confirm and further study.
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Clin Neurol Neurosurg · Oct 2013
Concomitant and adjuvant temozolomide of newly diagnosed glioblastoma in elderly patients.
The effect of concomitant and adjuvant temozolomide in glioblastoma patients above the age of 65 years lacks evidence. However, after combined treatment became standard at our center all patients were considered for combined therapy. We retrospectively analyzed the effect of temozolomide focused on elderly patients. ⋯ Retrospective matched pair analysis gives class 2b evidence for prolonged survival due to concomitant and adjuvant temozolomide in elderly glioblastoma patients. Until prospective data for combined radiochemotherapy in elderly patients will be available concomitant and adjuvant temozolomide therapy should not be withheld.