Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jan 2015
Meta AnalysisMigraine and breast cancer risk: a prospective cohort study and meta-analysis.
The evidence for an association between migraine and breast cancer risk is inconclusive. While female sex hormones have been proposed as one underlying mechanism, data on sex hormone levels in migraineurs are sparse. ⋯ In this large cohort study, migraine was not associated with breast cancer risk or differences in endogenous sex hormone levels. While case-control studies suggest an inverse association between migraine and breast cancer risk, prospective cohort studies do not support an association in pooled analyses.
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J. Natl. Cancer Inst. · Jan 2015
Randomized Controlled TrialCost-effectiveness of prostate cancer screening: a simulation study based on ERSPC data.
The results of the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial showed a statistically significant 29% prostate cancer mortality reduction for the men screened in the intervention arm and a 23% negative impact on the life-years gained because of quality of life. However, alternative prostate-specific antigen (PSA) screening strategies for the population may exist, optimizing the effects on mortality reduction, quality of life, overdiagnosis, and costs. ⋯ Prostate cancer screening can be cost-effective when it is limited to two or three screens between ages 55 to 59 years. Screening above age 63 years is less cost-effective because of loss of QALYs because of overdiagnosis.
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J. Natl. Cancer Inst. · Jan 2015
Comparative StudySelenium supplementation and prostate cancer mortality.
Few studies have evaluated the relation between selenium supplementation after diagnosis and prostate cancer outcomes. ⋯ Selenium supplementation of 140 or more μg/day after diagnosis of nonmetastatic prostate cancer may increase risk of prostate cancer mortality. Caution is warranted regarding usage of such supplements among men with prostate cancer.
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J. Natl. Cancer Inst. · Jan 2015
Germline mutations in shelterin complex genes are associated with familial glioma.
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing of 90 individuals from 55 families, we identified two families with mutations in POT1 (p. ⋯ D617Efs), also predicted to disrupt TPP1 binding. All families with POT1 mutations had affected members with oligodendroglioma, a specific subtype of glioma more sensitive to irradiation. These findings are important for understanding the origin of glioma and could have importance for the future diagnostics and treatment of glioma.