British journal of clinical pharmacology
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Br J Clin Pharmacol · Mar 2014
Review Meta AnalysisStatin use and risk of kidney cancer: a meta-analysis of observational studies and randomized trials.
Clinical studies have shown that statin use may modify the risk of kidney cancer. However, these studies yielded different results. To quantify the association between statin use and risk of kidney cancer, we performed a detailed meta-analysis of published studies regarding this subject. ⋯ The findings of this meta-analysis suggested that there was no association between statin use and risk of kidney cancer. More studies, especially randomized controlled trials and high quality cohort studies with larger sample size and well controlled confounding factors, are needed to confirm this association in the future.
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Br J Clin Pharmacol · Mar 2014
Randomized Controlled Trial Comparative StudyA repeat-dose thorough QT study of inhaled fluticasone furoate/vilanterol combination in healthy subjects.
This study was designed as a thorough QT (TQT) study to evaluate the effects of fluticasone furoate (FF)/vilanterol (VI) in healthy subjects. Supportive data from a TQT study conducted with FF are also presented. ⋯ Repeat once-daily dosing of FF/VI (200/25 μg), which is the highest therapeutic strength used in phase III studies, is not associated with QTc prolongation in healthy subjects. Supratherapeutic strength FF/VI (800/100 μg) demonstrated a small transient effect on QTcF but not on QTci.
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Br J Clin Pharmacol · Mar 2014
Letter Case ReportsInstantaneous rigor after fatal pholcodine intoxication.