The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia.
Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. ⋯ Among patients who had undergone mechanical ventilation for at least 3 days, a subsequent 3-day course of inhaled amikacin reduced the burden of ventilator-associated pneumonia during 28 days of follow-up. (Funded by the French Ministry of Health; AMIKINHAL ClinicalTrials.gov number, NCT03149640; EUDRA Clinical Trials number, 2016-001054-17.).
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Randomized Controlled Trial Multicenter Study Comparative Study
Decolonization in Nursing Homes to Prevent Infection and Hospitalization.
Nursing home residents are at high risk for infection, hospitalization, and colonization with multidrug-resistant organisms. ⋯ In nursing homes, universal decolonization with chlorhexidine and nasal iodophor led to a significantly lower risk of transfer to a hospital due to infection than routine care. (Funded by the Agency for Healthcare Research and Quality; Protect ClinicalTrials.gov number, NCT03118232.).
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Randomized Controlled Trial Multicenter Study
Trial of Botulinum Toxin for Isolated or Essential Head Tremor.
Local injections of botulinum toxin type A have been used to treat essential head tremor but have not been extensively studied in randomized trials. ⋯ Injection of botulinum toxin into each splenius capitis muscle on day 0 and during week 12 was more effective than placebo in reducing the severity of isolated or essential head tremor at 18 weeks but not at 24 weeks, when the effects of injection might be expected to wane, and was associated with adverse events. (Funded by the French Ministry of Health; Btx-HT ClinicalTrials.gov number, NCT02555982.).
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Randomized Controlled Trial Multicenter Study
Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.
Recurrent bleeding from the small intestine accounts for 5 to 10% of cases of gastrointestinal bleeding and remains a therapeutic challenge. Thalidomide has been evaluated for the treatment of recurrent bleeding due to small-intestinal angiodysplasia (SIA), but confirmatory trials are lacking. ⋯ In this placebo-controlled trial, treatment with thalidomide resulted in a reduction in bleeding in patients with recurrent bleeding due to SIA. (Funded by the National Natural Science Foundation of China and the Shanghai Municipal Education Commission, Gaofeng Clinical Medicine; ClinicalTrials.gov number, NCT02707484.).