Neuroscience
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Developmental dyscalculia (DD) is characterized by lower numerical and finger-related skills. Studies of enumeration among those DD that suggested core deficiency in pattern recognition, working memory or/and attention were mostly carried out in the visual modality. In our study, we examined visual (dots) enumeration of 1-10 stimuli and tactile (vibration) enumeration of 1-10 fingers among DD and matched-control adults. ⋯ In the tactile task, DD participants showed less accurate tactile enumeration only for neighboring arrangements, more profoundly for finger counting (FC) patterns. The longer exposure time in the visual task enabled us to explore pattern recognition effects when working memory and attention loads were low. We discuss possible modal-independent deficits in pattern recognition and working memory on enumeration performance among those with DD and the unique role of fingers in ordinal and cardinal representation of numbers.
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Given the fact that both melatonin and nicotinamide mononucleotide (NMN) act as pleiotropic agents in various age-related cognitive disorders, we aimed to investigate the effect of these compounds separately and together on the cognitive outcomes, mitochondrial function, and apoptosis in aged rats. Forty old and ten young (24 and 3 months old, respectively) male Wistar rats were randomly allocated into five groups: Young+Normal saline (NS), Aged+NS, Aged+Melatonin, Aged+NMN, and Aged+melatonin+NMN. Melatonin (10 mg/kg) and NMN (100 mg/kg) were administered, separately or in combination for 28 every other day in aged animals. ⋯ Behavioral results revealed that NMN and melatonin separately or in combination, alleviate aging-induced memory impairment. Moreover, agents' co-administration declined mitochondrial dysfunction and apoptotic cell count both in PFC and HIP regions. The agents separately or in combination (more potent) could induce neuroprotective effect and improve learning and memory in aged animals.
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The human capability to learn new motor skills depends on the efficient engagement of cognitive-motor resources, as reflected by mental workload, and psychological mechanisms (e.g., self-efficacy). While numerous investigations have examined the relationship between motor behavior and mental workload or self-efficacy in a performance context, a fairly limited effort focused on the combined examination of these notions during learning. Thus, this study aimed to examine their concomitant dynamics during the learning of a novel reaching skill practiced throughout multiple sessions. ⋯ However, as the performance becomes more automatic, a lower level of mental workload is attained driven by decreased recruitment of attentional resources. These available resources allow for a reliable assessment of self-efficacy resulting in a subsequent observable change. These results are also discussed in terms of the application to the training and design of assistive technologies.
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This study aims to investigate topological organization of cortical thickness and functional networks by cortical lobes. First, I demonstrated modular organization of these networks by the cortical surface frontal, temporal, parietal and occipital divisions. Secondly, I mapped the overlapping edges of cortical thickness and functional networks for positive and negative correlations. Finally, I showed that overlapping positive edges map onto within-lobe cortical interactions and negative onto between-lobes interactions.
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Adolescence is a period of extensive brain maturation. In particular, the regions of the medial prefrontal cortex (mPFC) undergo intense structural and functional refinement during adolescence. Disturbances in mPFC maturation have been implicated in the emergence of multiple psychopathologies during adolescence. ⋯ Moreover, MS induced anxiety-like behaviors, but not anhedonic-like behavior, in adolescents. These results suggest that ELS may disturb neurodevelopmental apoptosis of neurons and early-postnatal proliferation and/or apoptosis of different populations of glial cells in the PLC. ELS-induced aberrations in the postnatal maturation of the PLC may affect cortical network organization and functioning and determine vulnerability to psychopathologies in adolescents.