Neuroscience
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The human brain presents a heavily connected complex system. From a relatively fixed anatomy, it can enable a vast repertoire of functions. One important brain function is the process of natural sleep, which alters consciousness and voluntary muscle activity. ⋯ The results demonstrated that the delta-alpha coupling function was increasing gradually from Awake to NREM3 (non-rapid eye movement), but only during NREM2 and NREM3 deep sleep it was significant in respect of surrogate data testing. The analysis on the spatially distributed connections showed that this significance is strong only for within the single electrode region and in the front-to-back direction. The presented methodological framework is for the whole-night sleep recordings, but it also carries general implications for other global neural states.
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Ginkgo biloba L. leaf extract (GBE) has been added in many commercial herbal formulations such as EGb 761 and Shuxuening Injection to treat cardiovascular diseases and stroke worldwide. However, the comprehensive effects of GBE on cerebral ischemia remained unclear. Using a novel GBE (nGBE), which consists of all the compounds of traditional (t)GBE and one new compound, pinitol, we investigated its effect on inflammation, white matter integrity, and long-term neurological function in an experimental stroke model. ⋯ In vitro analyses showed that nGBE treatment reduced the production of IL-1β and TNFα in primary microglia. Administration of nGBE also decreased the SMI-32/MBP ratio and enhanced myelin integrity, thus exhibiting improved white matter integrity at 28 days post stroke. These findings demonstrate that nGBE protects against cerebral ischemia by inhibiting microglia-related inflammation and promoting white matter repair, suggesting that nGBE is a promising therapeutic strategy for long-term recovery after stroke.
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Dynamical, causal, and cross-frequency coupling analysis using the electroencephalogram (EEG) has gained significant attention for diagnosing and characterizing neurological disorders. Selecting important EEG channels is crucial for reducing computational complexity in implementing these methods and improving classification accuracy. In neuroscience, measures of (dis) similarity between EEG channels are often used as functional connectivity (FC) features, and important channels are selected via feature selection. ⋯ Our analysis shows significant differences in FC between bipolar channels of the occipital region and other regions (i.e. parietal, centro-parietal, and fronto-central) between AD and HC groups. Furthermore, our results indicate that FC changes between channels along the fronto-parietal region and the rest of the EEG are important in diagnosing AD. Our results and its relation to functional networks are consistent with those obtained from previous studies using fMRI, resting-state fMRI and EEG.
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Most neuroimaging studies investigating autism spectrum disorder (ASD) have focused on static brain function, but ignored the dynamic features of spontaneous brain activities in the temporal dimension. Research of dynamic brain regional activities might help to fully investigate the mechanisms of ASD patients. This study aimed to examine potential changes in the dynamic characteristics of regional neural activities in adult ASD patients and to detect whether the changes were associated with Autism Diagnostic Observation Schedule (ADOS) scores. ⋯ L was positively associated with ADOS_SOCIAL scores. In conclusion, adults with ASD have a wide area of dynamic regional brain function abnormalities. These suggested that dynamic regional indexes might be used as a powerful measure to help us obtain a more comprehensive understanding of neural activity in adult ASD patients.
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Propofol infusion is processed through the wake-sleep cycle in neural connections, and the ionotropic purine type 2X7 receptor (P2X7R) is a nonspecific cation channel implicated in sleep regulation and synaptic plasticity through its regulation of electric activity in the brain. Here, we explored the potential roles of P2X7R of microglia in propofol-induced unconsciousness. ⋯ Electrophysiological approaches showed that propofol induced a decreased frequency of sEPSCs and an increased frequency of sIPSCs, A-740003 decrease frequency of sEPSCs and sIPSCs and Bz-ATP increase frequency of sEPSCs and sIPSCs under propofol anesthesia. These findings indicated that P2X7R in microglia regulates synaptic plasticity and may contribute to propofol-mediated unconsciousness.