Spine
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Multicenter Study
Recruitment and early treatment in a multicenter study of acute spinal cord injury.
Post hoc secondary analysis of data from 1992 to 1998 in the trial of Sygen in Acute Spinal Cord Injury. ⋯ The imbalances in favor of cervical and of complete injuries would make it hard for studies to attain results for SCI in general. The vital signs and time patterns suggest local protocol-driven stabilization to prevent secondary physiologic injury early after SCI. Some features of care vary among centers, but the sparseness of prospective data in specific injury and treatment categories suggests that treatment guidelines have limited empirical support and should be made cautiously.
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Randomized Controlled Trial Multicenter Study Clinical Trial
The Sygen multicenter acute spinal cord injury study.
Randomized, double-blind, sequential, multicenter clinical trial of two doses of Sygen versus placebo. ⋯ Although not proven in the primary efficacy analysis of this trial, Sygen appears to be beneficial in patients with severe spinal cord injury.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group.
A randomized controlled multicenter study with a 2-year follow-up by an independent observer. ⋯ Lumbar fusion in a well-informed and selected group of patients with severe CLBP can diminish pain and decrease disability more efficiently than commonly used nonsurgical treatment.