Journal of medical virology
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Acute meningitis is perhaps the most frequent among central nervous system infections. We report a study considering 277 cases of meningitis hospitalized in the southern Tuscany area (Italy) during the period from 1995 to 1998 investigated by tissue culture and polymerase chain reaction (PCR) methods. ⋯ The viruses identified in the neurological infection were Toscana virus (81%), enterovirus (12%), mumps virus (3%), measles virus (1%), and herpes virus type 1 (3%). These data demonstrate the incisive role of the RNA viruses as the cause of meningitis, and overall the relevance of Toscana virus.
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To demonstrate the impact of influenza epidemics on pediatric hospital admissions, admissions that were attributable to influenza and respiratory syncytial virus (RSV) infection to the pediatric ward of an urban general hospital in Japan were followed-up during a 4-month period from December to March 1991 through 1998. During the 1997-1998 influenza type A (H3N2) epidemic, a diagnosis of influenza type A (H3N2) was made in 26.3% of all patients admitted aged 15 years or lower. During the peak of the epidemic, as many as 50-70% of the admissions were attributable to influenza type A (H3N2). ⋯ Among the patients with influenza, 74.5% of the cases were previously healthy children. Influenza and RSV infection are leading causes of pediatric hospital admissions during the winter. Effective methods of prophylaxis are needed not only for high-risk patients, but for healthy young children.