The American journal of medicine
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Clinical Trial Controlled Clinical Trial
25-Hydroxyvitamin D3 reverses alteration of the vitamin D-endocrine system in blacks.
Previous findings indicated that serum 25-hydroxyvitamin D and urinary calcium are decreased and serum immunoreactive parathyroid hormone, serum 1,25-dihydroxyvitamin D, and urinary cyclic adenosine 3',5'-monophosphate are increased in normal black compared to normal white subjects. Studies were carried out to determine if alteration of the vitamin D-endocrine system in blacks is reversed by oral supplementation with 25-hydroxyvitamin D3. ⋯ The results provide evidence that reduction of serum 25-hydroxyvitamin D contributes to or accounts for alteration of the vitamin D-endocrine system in black subjects.
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To evaluate the therapeutic and financial benefits of protocol therapy for acute asthma using standard medications. ⋯ Asthma protocol therapy, based primarily upon aggressive use of sympathomimetics in association with serial monitoring of key indices of improvement, provides prompt and efficient relief for acute exacerbations of asthma. Such an approach yields significant financial benefit while quickly identifying individuals who require hospitalization, and it also detects physician practice patterns that can have potentially detrimental impacts on patient care.
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Clinical Trial Controlled Clinical Trial
Reduction of cortisol levels after single intra-articular and intramuscular steroid injection.
This study was undertaken to determine the influence of single intra-articular or intra muscular injections of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis. ⋯ The present study suggests that decreased adrenocortical secretion, as reflected in depressed cortisol levels, can result from a single, low-dose, intra-articular or intramuscular injection of depot corticosteroids.