Developmental neuroscience
The most recent articles from:
Dev. Neurosci.
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Randomized Controlled Trial Multicenter Study
Hypothermia pediatric head injury trial: the value of a pretrial clinical evaluation phase.
The utility of a pretrial clinical evaluation or run-in phase prior to conducting trials of complex interventions such as hypothermia therapy following severe traumatic brain injury in children and adolescents has not been established. ⋯ The pretrial clinical evaluation phase was useful to ensure compliance with complex hypothermia therapy and consensus-based clinical management guidelines of care successfully implemented across 17 of 18 centers. This study maneuver allowed us to complete a subsequent RCT in 225 children following severe traumatic brain injury.