Journal of cancer research and clinical oncology

The most recent articles from: J. Cancer Res. Clin. Oncol. April 2002

J. Cancer Res. Clin. Oncol. · Apr 2002

Multicenter Study Clinical Trial

Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group.

To evaluate the antitumor effects and toxicities of whole brain irradiation (WBI) with temozolomide (TMZ) administered by prolonged oral dosing in patients with melanoma metastatic to the brain. ⋯ WBI has lower than expected activity in CNS metastasis of malignant melanoma. Although TMZ can be safely administered with WBI, the combination has limited anti-tumor activity.

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