Journal of cancer research and clinical oncology
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J. Cancer Res. Clin. Oncol. · Jun 2011
Meta AnalysisCapecitabine-based chemotherapy for metastatic colorectal cancer.
Metastatic colorectal cancer (MCRC) remains a significant public health concern. The objectives of present study are to investigate the efficacy and safety profile of capecitabine-based chemotherapy in the treatment of MCRC. ⋯ Capecitabine-based chemotherapy demonstrated a significantly superior progression-free survival, equivalent overall survival, and comparable response rate with 5-fluorouracil-based chemotherapy. These observations support the use of capecitabine-based chemotherapy in the treatment of MCRC as a first-line or as a neoadjuvant modality.